Can selective serotonin reuptake inhibitors (SSRI) improve motor recovery after stroke? What is the role of neuroplasticity?
نویسندگان
چکیده
منابع مشابه
Selective serotonin reuptake inhibitors to improve outcome in acute ischemic stroke: possible mechanisms and clinical evidence
BACKGROUND Several clinical studies have indicated that selective serotonin reuptake inhibitors (SSRIs) administered in patients after acute ischemic stroke can improve clinical recovery independently of depression. Due to small sample sizes and heterogeneous study designs interpretability was limited in these studies. The mechanisms of action whereby SSRI might improve recovery from acute isch...
متن کاملPrestroke selective serotonin reuptake inhibitor use and functional outcomes after ischaemic stroke
Background Selective serotonin reuptake inhibitors (SSRIs) have been implicated in contributing to recovery after acute ischaemic stroke. In particular, poststroke initiation of an SSRI has been demonstrated to improve motor recovery. The role of prestroke SSRI use on functional outcomes and stroke recovery is less clear. We aimed to examine the effect of prestroke SSRI use on metrics of hospit...
متن کاملSSRI and Motor Recovery in Stroke: Reestablishment of Inhibitory Neural Network Tonus
Selective serotonin reuptake inhibitors (SSRIs) are currently widely used in the field of the neuromodulation not only because of their anti-depressive effects but also due to their ability to promote plasticity and enhance motor recovery in patients with stroke. Recent studies showed that fluoxetine promotes motor recovery after stroke through its effects on the serotonergic system enhancing m...
متن کاملSelective serotonin reuptake inhibitors for stroke recovery.
CLINICAL QUESTION Are selective serotonin reuptake inhibitors (SSRIs) associated with better recovery after stroke? BOTTOM LINE SSRIs may be associated with improved recovery after stroke, even in persons without depression. However, much of the evidence is of poor quality. Large, high-quality trials are needed to evaluate the validity of the current evidence and improve precision of estimate...
متن کاملSelective serotonin reuptake inhibitors may be helpful in most patients with stroke.
T he clinical presentation of this patient with no past history of stroke shows a moderate to severe neurologi-cal deficit associating aphasia and hemiparesis (National Institutes of Health Stroke Scale, 14). Fugl-Meyer Motor Scale score of 35 indicates that some movements with his right side are possible but that he is probably bedridden and unable to walk. One can find several arguments to pr...
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ورودعنوان ژورنال:
- JPMA. The Journal of the Pakistan Medical Association
دوره 61 11 شماره
صفحات -
تاریخ انتشار 2011